克罗米酚对男性低促性腺素性功能减退症适当

纽约（汤森社健康版）1同年四日刊文：据公开发表在12同年月出版的《受孕与不育》杂志的一项统计数据引述克罗米醇对部份较低促性腺素性基本功能减退的未成年病症利于。来自伯明翰密苏里医学院的该统计数据的第一著者Scott J. Whitten哈佛大学在给与汤森通讯社采访时真是：“原发性或获得性HH病症在给与损害性大得多和更为昂贵的疗程（例如注射促性腺激素类）年前进行时4个同年的克罗米醇除此以外疗程是利于的。”Whitten哈佛大学和同事学术研究了克罗米醇对10名HH未成年病症（HH是致使未成年不育的典型各种因素）是否有效。统计数据称克罗米醇疗程1年后，4名卡尔曼(氏)肉瘤病症中只有一名病症的**含量增大而全脑下垂体基本功能减退症病症的**缺乏症状均未获取改善。意味著，该统计数据引述3名成年发病的原发性HH未成年病症经过3个同年克罗米醇的疗程**含量有了明显增大。目年前为止该组病症较早两名恢复了受孕能力。Whitten哈佛大学真是：“除非对克罗米醇疗程未反应，我们未因为药物停止对病症使用该药物。”最后著者阐释真是：“因为条件极小，对HH病症促性腺激素药物和克罗米醇的随机学术研究根本无法进行时，然而借助多系列的恰当选择标准对病症进行时级别可能帮助进一步验证克罗米醇恢复未成年较低受孕能力的实证。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

校对：蓝色未来世界

校对： 张靖